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These data suggest that PLA2R-Ab levels are early markers of rituximab effect and that addition of rituximab to NIAT does not affect safety.Īnti-PLA2R antibody anti-THSD7A antibody idiopathic membranous nephropathy randomized controlled trial rituximab severe adverse event.Ĭopyright © 2016 by the American Society of Nephrology.Pianoteq Crack with Keygenis a useful gizmo for any person who needs to remodel the pc into a flexible musical instrument. Positive effect of rituximab on proteinuria remission occurred after 6 months. During the observational phase, remission rates before change of assigned treatment were 24 of 37 (64.9%) and 13 of 38 (34.2%) patients in NIAT-rituximab and NIAT groups, respectively (P<0.01). Eight serious adverse events occurred in each group. Rates of antiphospholipase A2 receptor antibody (anti-PLA2R-Ab) depletion in NIAT-rituximab and NIAT groups were 14 of 25 (56%) and one of 23 (4.3%) patients at month 3 (P<0.001) and 13 of 26 (50%) and three of 25 (12%) patients at month 6 (P=0.004), respectively. At month 6, 13 (35.1% 95% confidence interval, 19.7 to 50.5) patients in the NIAT-rituximab group and eight (21.1% 95% CI, 8.1 to 34.0) patients in the NIAT group achieved remission (P=0.21). Primary outcome was a combined end point of complete or partial remission of proteinuria at 6 months. Median times to last follow-up were 17.0 (interquartile range, 12.5-24.0) months and 17.0 (interquartile range, 13.0-23.0) months in NIAT-rituximab and NIAT groups, respectively. Patients with biopsy-proven PMN and nephrotic syndrome after 6 months of nonimmunosuppressive antiproteinuric treatment (NIAT) were randomly assigned to 6-month therapy with NIAT and 375 mg/m 2 intravenous rituximab on days 1 and 8 (n=37) or NIAT alone (n=38). We undertook a multicenter, randomized, controlled trial at 31 French hospitals ( NCT01508468).
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Randomized trials of rituximab in primary membranous nephropathy (PMN) have not been conducted.
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1 Department of Nephrology and Dialysis, Assistance Publique Hôpitaux de Paris, Hôpital Tenon, Paris, France 2 Sorbonne Universités, Université Pierre et Marie Curie Paris 06, Paris, France.
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